BDBM423236 1-(5-(((3R,5R)-3- (hydroxymethyl)-5-(4- methyl-1-oxo-1,3- dihydroisobenzofuran- 5-yl)piperazin-1- yl)methyl)pyridin-2- yl)-3-methyl-1H- pyrazole-4-carbonitrile::US10501449, Example 130-I

SMILES C[C@H]1CN(Cc2coc(n2)-c2cc(C)c(cn2)C#N)C[C@H](N1)c1ccc2C(=O)OCc2c1C

InChI Key InChIKey=ACFCYMYINRCFSM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 423236   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423236(1-(5-(((3R,5R)-3- (hydroxymethyl)-5-(4- methyl-1-o...)
Affinity DataIC50: 20nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
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Date in BDB:
10/12/2020
Entry Details
US Patent