BDBM423242 4-methoxy-2-(4- (((3S,5R)-3-methyl-5- (4-methyl-1-oxo-1,3- dihydroisobenzofuran- 5-yl)piperazin-1- yl)methyl)-2H-1,2,3- triazol-2- yl)pyrimidine-5- carbonitrile::US10501449, Example 166-I

SMILES COc1nc(ncc1C#N)-n1ncc(CN2C[C@H](C)N[C@@H](C2)c2ccc3C(=O)OCc3c2C)n1

InChI Key InChIKey=KDKUTQCGAMTCIE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 423242   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423242(4-methoxy-2-(4- (((3S,5R)-3-methyl-5- (4-methyl-1-...)
Affinity DataIC50: 13nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent