BDBM423247 6-(4-((3,3-dimethyl-5- (4-methyl-1-oxo-1,3- dihydroisobenzofuran- 5-yl)piperazin-1- yl)methyl)-5-methyl- 2H-1,2,3-triazol-2-yl)- 4-methylnicotinonitrile (Enantiomer-I)::US10501449, Example 175-I

SMILES Cc1nn(nc1CN1CC(NC(C)(C)C1)c1ccc2C(=O)OCc2c1C)-c1cc(C)c(cn1)C#N

InChI Key InChIKey=UGNJOBSGYFQSAS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 423247   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423247(6-(4-((3,3-dimethyl-5- (4-methyl-1-oxo-1,3- dihydr...)
Affinity DataIC50: 17nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent