BDBM423249 (R)-4-methoxy-2- methyl-6-(4-((3-(4- methyl-1-oxo-1,3- dihydroisobenzofuran- 5-yl)piperaizn-1- yl)methyl)-1H-1,2,3- triazol-1- yl)nicotinonitrile::US10501449, Example 187-I

SMILES COc1cc(nc(C)c1C#N)-n1cc(CN2CCN[C@@H](C2)c2ccc3C(=O)OCc3c2C)nn1

InChI Key InChIKey=KCSCDIKSKJXEKY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 423249   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423249((R)-4-methoxy-2- methyl-6-(4-((3-(4- methyl-1-oxo-...)
Affinity DataIC50: 25nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent