BDBM423261 (R)-4-methyl-2-(4-((3- (4-methyl-1-oxo-1,3- dihydroisobenzofuran- 5-yl)piperazin-1- yl)methyl)-1H-pyrazol- 1-yl)pyrimidine-5- carbonitrile::US10501449, Example 230-I

SMILES Cc1nc(ncc1C#N)-n1cc(CN2CCN[C@@H](C2)c2ccc3C(=O)OCc3c2C)cn1

InChI Key InChIKey=CKBVZOQTUBGLTC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 423261   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423261((R)-4-methyl-2-(4-((3- (4-methyl-1-oxo-1,3- dihydr...)
Affinity DataIC50: 19nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent