BDBM423266 6-(5-((3,3- dimethyl-5- (4-methyl- 1-oxo-1,3- dihydroiso- benzofuran- 5-yl)piperazin-1- yl)methyl)-1,3,4- oxadiazol-2-yl)- 4-methylnico- tinonitrile (Enantiomer-I)::US10501449, Example 267-I

SMILES Cc1cc(ncc1C#N)-c1nnc(CN2CC(NC(C)(C)C2)c2ccc3C(=O)OCc3c2C)o1

InChI Key InChIKey=IIIDYIDJAOEJEX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 423266   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423266(6-(5-((3,3- dimethyl-5- (4-methyl- 1-oxo-1,3- dihy...)
Affinity DataIC50: 17nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent