BDBM428834 US20250092017, Compound P3

SMILES CC(C)c6ccc(N2CC1(CC(S(C)(=O)=O)C1)C2)c7cnc(Nc5ccnc(c4cnn(S(=O)(=O)C3CC3)c4)n5)cc67

InChI Key InChIKey=FAFVCTFZKBEMCC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 428834   

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Suzhou Puhe Biopharma Co.

US Patent
LigandPNGBDBM428834(US20250092017, Compound P3)
Affinity DataIC50: 0.710nMAssay Description:The MSA (Mobility Shift Assay) method was used to detect the effects of small molecule inhibitors on the kinase activity of EGFR wild type and its mu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Suzhou Puhe Biopharma Co.

US Patent
LigandPNGBDBM428834(US20250092017, Compound P3)
Affinity DataIC50: 5.80nMAssay Description:The MSA (Mobility Shift Assay) method was used to detect the effects of small molecule inhibitors on the kinase activity of EGFR wild type and its mu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Suzhou Puhe Biopharma Co.

US Patent
LigandPNGBDBM428834(US20250092017, Compound P3)
Affinity DataIC50: 10.6nMAssay Description:The MSA (Mobility Shift Assay) method was used to detect the effects of small molecule inhibitors on the kinase activity of EGFR wild type and its mu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Suzhou Puhe Biopharma Co.

US Patent
LigandPNGBDBM428834(US20250092017, Compound P3)
Affinity DataIC50: 17.9nMAssay Description:The MSA (Mobility Shift Assay) method was used to detect the effects of small molecule inhibitors on the kinase activity of EGFR wild type and its mu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent