BDBM429554 (2-(3,3- Difluoropyrrolidin-1- yl)-4-fluorophenyl)(1H- imidazol-2-yl)methanol::US10550089, Example 28::US10995072, Example 28

SMILES OC(c1ncc[nH]1)c1ccc(F)cc1N1CCC(F)(F)C1

InChI Key InChIKey=GFAKZJPCYUPRTP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 429554   

TargetProteinase-activated receptor 2(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM429554((2-(3,3- Difluoropyrrolidin-1- yl)-4-fluorophenyl)...)
Affinity DataIC50: 4.91E+3nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent

TargetProteinase-activated receptor 2(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM429554((2-(3,3- Difluoropyrrolidin-1- yl)-4-fluorophenyl)...)
Affinity DataIC50: 4.91E+3nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetProteinase-activated receptor 2(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM429554((2-(3,3- Difluoropyrrolidin-1- yl)-4-fluorophenyl)...)
Affinity DataIC50: 3.03E+4nMAssay Description:Calcium mobilization was measured using 1321N1 cells stably expressing human PAR2. Cells were seeded in 384-well plates at 4,000 cells per well in 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent

TargetProteinase-activated receptor 2(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM429554((2-(3,3- Difluoropyrrolidin-1- yl)-4-fluorophenyl)...)
Affinity DataIC50: 3.03E+4nMAssay Description:Calcium mobilization was measured using 1321N1 cells stably expressing human PAR2. Cells were seeded in 384-well plates at 4,000 cells per well in 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent