BDBM430275 US10556885, Compound 6

SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)[C@@H]3CC[C@@H](CC3)N3CCOCC3)cc2c1

InChI Key InChIKey=XAKZFQZFGKCPNZ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 430275   

LigandPNGBDBM430275(US10556885, Compound 6)
Affinity DataEC50:  1.30nMAssay Description:The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions. This is a non-radioactive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
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TargetGlycogen synthase kinase-3 beta(Human)
Samumed

US Patent
LigandPNGBDBM430275(US10556885, Compound 6)
Affinity DataEC50:  65nMAssay Description:GSK3B: This is a non-radioactive assay using fluorescence resonance energy transfer (FRET) between coumarin and fluorescein to detect kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent