BDBM4304 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamide::CHEMBL56731::cid_5328771::tyrphostin 1

SMILES Oc1ccc(\C=C(/C#N)C(=O)Nc2ccccc2)cc1O

InChI Key InChIKey=HKHOVJYOELRGMV-UHFFFAOYSA-N

Data  13 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 4304   

TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4304(cid_5328771 | CHEMBL56731 | (2E)-2-cyano-3-(3,4-di...)
Affinity DataIC50: 700nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4304(cid_5328771 | CHEMBL56731 | (2E)-2-cyano-3-(3,4-di...)
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4304(cid_5328771 | CHEMBL56731 | (2E)-2-cyano-3-(3,4-di...)
Affinity DataIC50: 1.00E+4nMAssay Description:The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2005
Entry Details Article
PubMed
TargetLarge T antigen(SV40)
Southern Research Specialized Biocontainment Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM4304(cid_5328771 | CHEMBL56731 | (2E)-2-cyano-3-(3,4-di...)
Affinity DataEC50: >5.00E+4nMAssay Description:Southern Research's Specialized Biocontainment Screening Center (SRSBSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Librarie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2011
Entry Details
PCBioAssay
TargetProthrombin(Bovine)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM4304(cid_5328771 | CHEMBL56731 | (2E)-2-cyano-3-(3,4-di...)
Affinity DataIC50: 6.79E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
Target26S proteasome non-ATPase regulatory subunit 14(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM4304(cid_5328771 | CHEMBL56731 | (2E)-2-cyano-3-(3,4-di...)
Affinity DataIC50: 1.30E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Oregon

Curated by ChEMBL
LigandPNGBDBM4304(cid_5328771 | CHEMBL56731 | (2E)-2-cyano-3-(3,4-di...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of ERBB2 receptor autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4304(cid_5328771 | CHEMBL56731 | (2E)-2-cyano-3-(3,4-di...)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2C(Rat)
University of Oregon

Curated by ChEMBL
LigandPNGBDBM4304(cid_5328771 | CHEMBL56731 | (2E)-2-cyano-3-(3,4-di...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2C.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rat)
University of Oregon

Curated by ChEMBL
LigandPNGBDBM4304(cid_5328771 | CHEMBL56731 | (2E)-2-cyano-3-(3,4-di...)
Affinity DataIC50: 9.00E+4nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Oregon

Curated by ChEMBL
LigandPNGBDBM4304(cid_5328771 | CHEMBL56731 | (2E)-2-cyano-3-(3,4-di...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2A.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4304(cid_5328771 | CHEMBL56731 | (2E)-2-cyano-3-(3,4-di...)
Affinity DataIC50: 700nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4304(cid_5328771 | CHEMBL56731 | (2E)-2-cyano-3-(3,4-di...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Oregon

Curated by ChEMBL
LigandPNGBDBM4304(cid_5328771 | CHEMBL56731 | (2E)-2-cyano-3-(3,4-di...)
Affinity DataIC50: 4.17E+4nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed