BDBM4308 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)prop-2-enamide::CHEMBL440298::Tyrphostin deriv. 56

SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCCc2ccccc2)cc1O

InChI Key InChIKey=GWCNJMUSWLTSCW-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 4308   

TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4308(CHEMBL440298 | (2E)-2-cyano-3-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 1.10E+3nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Oregon

Curated by ChEMBL
LigandPNGBDBM4308(CHEMBL440298 | (2E)-2-cyano-3-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of ERBB2 receptor autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Oregon

Curated by ChEMBL
LigandPNGBDBM4308(CHEMBL440298 | (2E)-2-cyano-3-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2A.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2C(Rat)
University of Oregon

Curated by ChEMBL
LigandPNGBDBM4308(CHEMBL440298 | (2E)-2-cyano-3-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2C.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4308(CHEMBL440298 | (2E)-2-cyano-3-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rat)
University of Oregon

Curated by ChEMBL
LigandPNGBDBM4308(CHEMBL440298 | (2E)-2-cyano-3-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 560nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
University of Oregon

Curated by ChEMBL
LigandPNGBDBM4308(CHEMBL440298 | (2E)-2-cyano-3-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Oregon

Curated by ChEMBL
LigandPNGBDBM4308(CHEMBL440298 | (2E)-2-cyano-3-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 5.01E+5nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4308(CHEMBL440298 | (2E)-2-cyano-3-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed