BDBM431795 US10550105, Example 661

SMILES C[C@@H](COCCC(=O)N1CCN(CC1)c2ncc(cn2)C(F)(F)F)NC3=C(C(=O)NN=C3)C(F)(F)F

InChI Key InChIKey=UQZCQKXJAXKZQH-UHFFFAOYSA-N

Data  4 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 431795   

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Guizhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 431795BDBM431795(US10550105, Example 661)
Affinity DataKd:  0.220nMAssay Description:Binding affinity to PARP7 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Guizhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 431795BDBM431795(US10550105, Example 661)
Affinity DataIC50: 3nMAssay Description:Inhibition of PARP7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Guizhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 431795BDBM431795(US10550105, Example 661)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of PARP7 (unknown origin) using histone as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Guizhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 431795BDBM431795(US10550105, Example 661)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of PARP7 (unknown origin) incubated for 1 hr by chemiluminescence based microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 431795BDBM431795(US10550105, Example 661)
Affinity DataIC50: 17nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed