BDBM431877 US10550114, Compound 32

SMILES C=CC(=O)Nc1cccc(c1)C(=O)NC1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1

InChI Key InChIKey=NIVNUJQVBHZNPS-UHFFFAOYSA-N

Data  1 KI  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 431877   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431877(US10550114, Compound 32)
Affinity DataIC50: 1.5nMAssay Description:iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431877(US10550114, Compound 32)
Affinity DataIC50: 2.70nMAssay Description:iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431877(US10550114, Compound 32)
Affinity DataIC50: 3.60nMAssay Description:Covalent-allosteric inhibition of full length N-terminal his6-tagged AKT (2 to 446 residues) (unknown origin) expressed in Spodoptera frugiperda Sf9 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431877(US10550114, Compound 32)
Affinity DataKi:  4.60nMAssay Description:iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431877(US10550114, Compound 32)
Affinity DataKi:  6.80nMAssay Description:Covalent-allosteric inhibition of full length N-terminal his6-tagged AKT (2 to 446 residues) (unknown origin) expressed in Spodoptera frugiperda Sf9 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431877(US10550114, Compound 32)
Affinity DataKd:  216nMAssay Description:iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase [E17K](Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431877(US10550114, Compound 32)
Affinity DataIC50: 525nMAssay Description:iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent