BDBM432273 N-(1-benzylpiperidin-4-yl)-N-(1-phenyl-1H-1,2,3-triazol-4-yl)thiophene-2-::US10577360, Example 136::US10577360, Example 137

SMILES O=C(N(C1CCN(Cc2ccccc2)CC1)c1cn(nn1)-c1ccccc1)c1cccs1

InChI Key InChIKey=MKXVLTLTANCGBG-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 432273   

TargetMu-type opioid receptor(Human)
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM432273(N-(1-benzylpiperidin-4-yl)-N-(1-phenyl-1H-1,2,3-tr...)
Affinity DataKi: <100nMAssay Description:To investigate binding properties of test compounds to human μ-opioid receptor, transfected CHO-K1 cell membranes and [3H]-DAMGO (Perkin Elmer, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM432273(N-(1-benzylpiperidin-4-yl)-N-(1-phenyl-1H-1,2,3-tr...)
Affinity DataKi: <100nMAssay Description:To investigate binding properties of test compounds to human μ-opioid receptor, transfected CHO-K1 cell membranes and [3H]-DAMGO (Perkin Elmer, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM432273(N-(1-benzylpiperidin-4-yl)-N-(1-phenyl-1H-1,2,3-tr...)
Affinity DataKi: >5.00E+3nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM432273(N-(1-benzylpiperidin-4-yl)-N-(1-phenyl-1H-1,2,3-tr...)
Affinity DataKi: >5.00E+3nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent