BDBM435722 US10570155, Compound 31III

SMILES Oc1cccc(c1)-c1nc2sccn2c1-c1ccnc(NCCCNS(=O)(=O)c2ccc(F)cc2)n1

InChI Key InChIKey=PORCJONFOOECRV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 435722   

TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435722(US10570155, Compound 31III)
Affinity DataIC50: 4.19nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435722(US10570155, Compound 31III)
Affinity DataIC50: 0.980nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435722(US10570155, Compound 31III)
Affinity DataIC50: 7.83nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435722(US10570155, Compound 31III)
Affinity DataIC50: 7.83E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435722(US10570155, Compound 31III)
Affinity DataIC50: 4.19E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435722(US10570155, Compound 31III)
Affinity DataIC50: 980nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed