BDBM435778 2-(2,6-dichlorophenyl)-1- ((1S,3R)-3-(hydroxymethyl)-1- methyl-5-(1-(oxetan-3-yl)-1H- pyrazol-4-yl)-3,4- dihydroisoquinolin-2(1H)- yl)ethan-1-one::US10611751, Example 4

SMILES C[C@@H]1N([C@@H](CO)Cc2c1cccc2-c1cnn(c1)C1COC1)C(=O)Cc1c(Cl)cccc1Cl

InChI Key InChIKey=LUYDFMYIIATRPY-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 435778   

TargetD(1A) dopamine receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM435778(US10611751, Example 4 | 2-(2,6-dichlorophenyl)-1- ...)
Affinity DataEC50:  28.5nMAssay Description:The PAM activity of the compounds of the present invention may be measured essentially as described in Svensson et al., An Allosteric Potentiator of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetD(1A) dopamine receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM435778(US10611751, Example 4 | 2-(2,6-dichlorophenyl)-1- ...)
Affinity DataEC50:  26nMAssay Description:Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed