BDBM435978 (+-)-5-[2-Methyl-3-[[2-(trifluoromethyl)morpholin-4-yl]methyl]phenyl]-1,3-::US10611730, Example 151

SMILES Cc1c(CN2CCOC(C2)C(F)(F)F)cccc1-c1ccc2[nH]c(=O)[nH]c2c1

InChI Key InChIKey=AQFKTEDMACORIG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 435978   

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM435978(US10611730, Example 151 | (+-)-5-[2-Methyl-3-[[2-(...)
Affinity DataIC50: 31.6nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
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Date in BDB:
12/7/2020
Entry Details
US Patent