BDBM436219 US10590114, No. 11::US11111235, No. 11

SMILES CNc1nc(Nc2cnn(C3C[C@H]4[C@@H](C3)C4(F)F)c2C)ncc1C(F)(F)F

InChI Key InChIKey=FSZAPCSJHYOKQG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 436219   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Denali Therapeutics

US Patent
LigandPNGBDBM436219(US10590114, No. 11 | US11111235, No. 11)
Affinity DataIC50: 30nMAssay Description:Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme Reaction Conditions50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Denali Therapautics

US Patent
LigandPNGBDBM436219(US10590114, No. 11 | US11111235, No. 11)
Affinity DataIC50: 30nMAssay Description:Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well assay plate DMSOEnzyme Reaction Condition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent