BDBM438062 US10597366, Compound 317::US10597366, Compound 321

SMILES CS(=O)(=NC#N)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@H](F)C(F)(F)[C@H](O)c12

InChI Key InChIKey=YEUWSUWCOJCFQV-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 438062   

TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

US Patent
LigandPNGBDBM438062(US10597366, Compound 321 | US10597366, Compound 31...)
Affinity DataIC50: 5nMAssay Description:HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetVascular endothelial growth factor A(Human)
Peloton Therapeutics

US Patent
LigandPNGBDBM438062(US10597366, Compound 321 | US10597366, Compound 31...)
Affinity DataEC50:  14nMAssay Description:VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

US Patent
LigandPNGBDBM438062(US10597366, Compound 321 | US10597366, Compound 31...)
Affinity DataIC50: 32nMAssay Description:HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent