BDBM438089 US10597366, Compound 344::US10597366, Compound 345

SMILES O[C@H]1c2c([C@@H](F)C1(F)F)c(Oc1cncc(c1)C#N)ccc2S(=O)(=O)CF

InChI Key InChIKey=MDIUIJMBPAVHPC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 438089   

TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

US Patent
LigandPNGBDBM438089(US10597366, Compound 345 | US10597366, Compound 34...)
Affinity DataIC50: 6.70nMAssay Description:HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

US Patent
LigandPNGBDBM438089(US10597366, Compound 345 | US10597366, Compound 34...)
Affinity DataIC50: 2.18E+3nMAssay Description:HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent