BDBM438600 US10618902, Compound I-281

SMILES COc1cc(OC)c(F)c(c1F)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)nc2n(C)c1=O

InChI Key InChIKey=PSKWUEAQZZDBSQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 438600   

TargetFibroblast growth factor receptor 4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM438600(US10618902, Compound I-281)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of recombinant human wild type N-His tagged FGFR4 (460-802) using Y10-Sox as substrate in presence of 250 uM ATP by Omnia kinase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM438600(US10618902, Compound I-281)
Affinity DataIC50: 11nMAssay Description:Inhibition of FGFR4 (unknown origin) expressed in human Huh7 cells assessed as autophosphorylation after 1 hr incubation measured by Mesoscale discov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM438600(US10618902, Compound I-281)
Affinity DataIC50: 500nMAssay Description:A 10× stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM438600(US10618902, Compound I-281)
Affinity DataIC50: 672nMAssay Description:Inhibition of recombinant human tagged FGFR2 using Y10-Sox as substrate in presence of 250 uM ATP by Omnia kinase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM438600(US10618902, Compound I-281)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of FGFR2 (unknown origin) expressed in KATO -III cells assessed as autophosphorylation after 1 hr incubation measured by Mesoscale discove...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed