BDBM439310 US10633348, Compound (A-8)

SMILES CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(Oc4cc(NC)ncn4)c3)cc2C(F)(F)F)CC1

InChI Key InChIKey=FCNPQYHKUYSELK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 439310   

TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 439310BDBM439310(US10633348, Compound (A-8))
Affinity DataIC50: 31nMAssay Description:Inhibition of MAP4K2 (unknown origin) Lys1 labeling site by KiNativ Profiling analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 439310BDBM439310(US10633348, Compound (A-8))
Affinity DataIC50: 250nMAssay Description:Inhibition of p38 alpha (unknown origin) by KiNativ Profiling analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Fes/Fps(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 439310BDBM439310(US10633348, Compound (A-8))
Affinity DataIC50: 252nMAssay Description:Inhibition of FES (unknown origin) by KiNativ Profiling analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 439310BDBM439310(US10633348, Compound (A-8))
Affinity DataIC50: 364nMAssay Description:Inhibition of TAK1 (unknown origin) Lys2 labeling site by KiNativ Profiling analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Fer(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 439310BDBM439310(US10633348, Compound (A-8))
Affinity DataIC50: 577nMAssay Description:Inhibition of FER (unknown origin) ACT labeling site by KiNativ Profiling analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed