BDBM443438 US10654866, Example 5::US11117902, Example 5::US11634426, Example 5

SMILES Oc1ccc2c3C(Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1

InChI Key InChIKey=OGEAHDJGRDNLQY-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 443438   

TargetEstrogen receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM443438(US10654866, Example 5 | US11117902, Example 5 | US...)
Affinity DataKi:  2.82nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM443438(US10654866, Example 5 | US11117902, Example 5 | US...)
Affinity DataKi:  2.82nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM443438(US10654866, Example 5 | US11117902, Example 5 | US...)
Affinity DataKi:  2.82nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent

TargetEstrogen receptor [Y537S](Human)
Eli Lilly

US Patent
LigandPNGBDBM443438(US10654866, Example 5 | US11117902, Example 5 | US...)
Affinity DataKi:  19.5nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetEstrogen receptor [Y537S](Human)
Eli Lilly

US Patent
LigandPNGBDBM443438(US10654866, Example 5 | US11117902, Example 5 | US...)
Affinity DataKi:  19.5nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetEstrogen receptor [Y537S](Human)
Eli Lilly

US Patent
LigandPNGBDBM443438(US10654866, Example 5 | US11117902, Example 5 | US...)
Affinity DataKi:  19.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent