BDBM445648 US10683294, Compound 1.053::US11479553, Compound 1.053

SMILES Cc1cccc(C)c1-n1nc2CN(CC(C)(C)C)Cc2c1-c1ccc2[nH]ccc2c1

InChI Key InChIKey=DKPNJHNAXXZXLQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 445648   

TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Chemocentryx

US Patent
LigandPNGBDBM445648(US10683294, Compound 1.053 | US11479553, Compound ...)
Affinity DataIC50: 275nMAssay Description:cAMP treated U937 cells expressing C5aR were centrifuged and resuspended in assay buffer (20 mM HEPES pH 7.1, 140 mM NaCl, 1 mM CaCl2, 5 mM MgCl2, an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
Go to US Patent

TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Chemocentryx

US Patent
LigandPNGBDBM445648(US10683294, Compound 1.053 | US11479553, Compound ...)
Affinity DataIC50: 500nMAssay Description:To evaluate small organic molecules that prevent the C5a receptor from binding ligand, an assay was employed that detected radioactive ligand (i.e, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
Go to US Patent

TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Chemocentryx

US Patent
LigandPNGBDBM445648(US10683294, Compound 1.053 | US11479553, Compound ...)
Affinity DataIC50: 275nMAssay Description:To evaluate small organic molecules that prevent the C5a receptor from binding ligand, an assay was employed that detected radioactive ligand (i.e, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
Go to US Patent