BDBM446021 US10669246, Example 72::US10968188, Example 72

SMILES F[C@H]1C[C@H]1C(=O)Nc1nc2ccc(cc2s1)-c1cnccc1C(F)(F)F

InChI Key InChIKey=LZEQACNRBCGEJG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 446021   

TargetTyrosine-protein kinase ABL1(Human)
Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM446021(US10669246, Example 72 | US10968188, Example 72)
Affinity DataIC50: 62nMAssay Description:Inhibition of recombinant human His-tagged c-Abl kinase assessed as luminescence incubated for 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM446021(US10669246, Example 72 | US10968188, Example 72)
Affinity DataIC50: 63.5nMAssay Description:ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM446021(US10669246, Example 72 | US10968188, Example 72)
Affinity DataIC50: 63.5nMAssay Description:c-abl kinase activity was measured by Promega's ADP-Glo Assay. In this assay, His-tagged recombinant human ABL1 (0.25 ng/μl) is incubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent