BDBM446066 2-chloro-6-fluoro-N-(2-{4-[(4-fluorophenyl)methoxy]piperidin-1- yl]}-2-(4-methyl-1,3-thiazol-5-yl)ethyl)benzamide::US10669267, Compound 1
SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)OCc1ccc(F)cc1
InChI Key InChIKey=FFDIXSSLNPIQTO-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 446066
Affinity DataIC50: 45nMAssay Description:In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.04E+3nMAssay Description:Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest ). B...More data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of human P2X7 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of rat P2X7 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair