BDBM446067 2-chloro-6-fluoro-N-(2-{4-[(3-fluorophenyl)methoxy]piperidin-1- yl}-2-(4-methyl-1,3-thiazol-5-yl)ethyl)benzamide::US10669267, Compound 3
SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)OCc1cccc(F)c1
InChI Key InChIKey=ODRRCFJWLSSRKZ-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 446067
Affinity DataIC50: 5.95nMAssay Description:In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...More data for this Ligand-Target Pair
Affinity DataIC50: 373nMAssay Description:Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest ). B...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human P2X7 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 373nMAssay Description:Inhibition of rat P2X7 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair