BDBM446076 N-(2-{4-[(3-fluorophenyl)methoxy]piperidin-1-yl}-2-(4-methyl- 1,3-thiazol-5-yl)ethyl)quinoline-5-carboxamide::US10669267, Compound 15

SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1cccc(F)c1

InChI Key InChIKey=SNDJPLCRJXJGCX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 446076   

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM446076(N-(2-{4-[(3-fluorophenyl)methoxy]piperidin-1-yl}-2...)
Affinity DataIC50: 11.6nMAssay Description:In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Axxam

US Patent
LigandPNGBDBM446076(N-(2-{4-[(3-fluorophenyl)methoxy]piperidin-1-yl}-2...)
Affinity DataIC50: 288nMAssay Description:Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest ). B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent