BDBM446086 N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(4- fluorophenoxy)piperidin-1-yl]ethyl}quinoline-5-carboxamide::US10669267, Compound 34

SMILES FC(F)c1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccc(F)cc1

InChI Key InChIKey=JAMHJKGTNOJCMR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 446086   

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM446086(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(4...)
Affinity DataIC50: 39.7nMAssay Description:In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Axxam

US Patent
LigandPNGBDBM446086(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(4...)
Affinity DataIC50: 144nMAssay Description:Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest ). B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Axxam

US Patent
LigandPNGBDBM446086(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(4...)
Affinity DataIC50: 144nMAssay Description:Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest ). B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent