BDBM446680 US10669289, Compound 87

SMILES Cc1ccc(C[C@H](NC(=O)CN(C(=O)C=C)c2ccccc2Cl)B(O)O)c(C)c1

InChI Key InChIKey=FLLFBSQOQHBDMP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 446680   

TargetProteasome subunit beta type-8(Human)
Merck Patent

US Patent
LigandPNGBDBM446680(US10669289, Compound 87)
Affinity DataIC50: 50nMAssay Description:Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immuno proteasome (0.25 nM) and s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent

TargetProteasome subunit beta type-5(Human)
Merck Patent

US Patent
LigandPNGBDBM446680(US10669289, Compound 87)
Affinity DataIC50: 5.00E+3nMAssay Description:Measurement of Beta5 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human constitutive proteasome (1.25 nM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent