BDBM447444 (2S,4R)-4-(2-chloro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenylsulfonyl)-N-(1-cyanocyclopropyl)-1-(1-(trifluoromethyl)cyclopropanecarbonyl)pyrrolidine-2-carboxamide::US10689339, Example 52

SMILES Cc1ncnn1-c1ccc(c(Cl)c1)S(=O)(=O)[C@@H]1C[C@H](N(C1)C(=O)C1(CC1)C(F)(F)F)C(=O)NC1(CC1)C#N

InChI Key InChIKey=FCEHZCPWCJMNSI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 447444   

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447444(US10689339, Example 52 | (2S,4R)-4-(2-chloro-4-(5-...)
Affinity DataIC50: 0.486nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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