BDBM448361 Perampanel, 14

SMILES Clc1cc(OCc2ccccc2)cc(c1)C1C=C(C(=O)N(C1=O)c1cccnc1)c1c[nH]c(=O)[nH]c1=O

InChI Key InChIKey=ORDPDTSDGPEXOP-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 448361   

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM448361(Perampanel, 14)
Affinity DataIC50: 128nMAssay Description:Inhibition of proteolytic activity was tested using recombinant SARS-CoV-2Mpro, which was expressed and purified as previously described.8,12 For the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM448361(Perampanel, 14)
Affinity DataEC50:  3.20E+3nMAssay Description:Vero-E6 cells were seeded at 4 x 10E5 cells/well in 12-well plates and infected for 1 hour with the SARS-CoV-2 isolate USA-WA1/2020 at an MOI of 0.01...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article