BDBM448926 1-(2-((5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)-2-hydroxyethan-1-one::US10696678, Example 21::US11351170, Example 5

SMILES CC1(C)CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CO)ncc1F

InChI Key InChIKey=VDTYYNPPVROBPA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 448926   

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448926(1-(2-((5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihyd...)
Affinity DataIC50: 1.76E+4nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
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Date in BDB:
3/2/2021
Entry Details
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TargetCyclin-dependent kinase 4(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM448926(1-(2-((5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihyd...)
Affinity DataIC50: 0.120nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
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Date in BDB:
9/10/2022
Entry Details
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TargetCyclin-dependent kinase 6(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM448926(1-(2-((5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihyd...)
Affinity DataIC50: 1.87nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were respectively dissolved in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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TargetCyclin-dependent kinase 2(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM448926(1-(2-((5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihyd...)
Affinity DataIC50: 17.6nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
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Date in BDB:
9/10/2022
Entry Details
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TargetCyclin-dependent kinase 5(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM448926(1-(2-((5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihyd...)
Affinity DataIC50: 36.8nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent