BDBM448945 (R)-5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)-N-(5-(3-methylpiperazin-1-yl)pyridin-2-yl)pyrimidin-2-amine::US10696678, Example 40

SMILES C[C@@H]1CN(CCN1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCC(C)(C)n4c3c2)nc1

InChI Key InChIKey=FFQWDZFHWMXCGK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 448945   

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448945((R)-5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-...)
Affinity DataIC50: 200nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 1(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448945((R)-5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-...)
Affinity DataIC50: 275nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448945((R)-5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-...)
Affinity DataIC50: 600nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent