BDBM450445 2-[6-(4-Acetylpiperazin-1-yl)-4-oxoquinazolin-3-yl]-N-[(4-chloro-3-cyanophenyl)methyl]-N-methylacetamide::US10676446, Example 57

SMILES CN(Cc1ccc(Cl)c(c1)C#N)C(=O)Cn1cnc2ccc(cc2c1=O)N1CCN(CC1)C(C)=O

InChI Key InChIKey=HSZSZDKAEHGVSQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 450445   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM450445(US10676446, Example 57 | 2-[6-(4-Acetylpiperazin-1...)
Affinity DataIC50: 8nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
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Date in BDB:
3/10/2021
Entry Details
Go to US Patent