BDBM450616 Sodium (2S,3R)-3-cyclopropyl-3-((R or S)-2-(2′-fluoro-5′-methoxy-[1,1′-biphenyl]-4-yl)-1,2,3,4-tetrahydroquinolin-7-yl)-2-methylpropanoate (Example 11); and (2S,3R)-3-cyclopropyl-3-((S or R)-2-(2′-fluoro-5′-methoxy-[1,1′-biphenyl]-4-yl)-1,2,3,4-tetrahydroquinolin-7-yl)-2-methylpropanoic acid (Example 12)::US10676458, Example 11::US10676458, Example 12

SMILES COc1ccc(F)c(c1)-c1ccc(cc1)C1CCc2ccc(cc2N1)[C@@H]([C@H](C)C([O-])=O)C1CC1

InChI Key InChIKey=MFAXDYLIDNLMDA-UHFFFAOYSA-M

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 450616   

TargetFree fatty acid receptor 1(Human)
Merch Sharp & Dohne Corp. Rahway

US Patent
LigandPNGBDBM450616(US10676458, Example 11 | Sodium (2S,3R)-3-cyclopro...)
Affinity DataEC50:  0.790nMAssay Description:The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetFree fatty acid receptor 1(Human)
Merch Sharp & Dohne Corp. Rahway

US Patent
LigandPNGBDBM450616(US10676458, Example 11 | Sodium (2S,3R)-3-cyclopro...)
Affinity DataEC50:  0.200nMAssay Description:The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 7500 cells per well in growth medium (DMEM/10% fet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent