BDBM450969 5-(((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(4-methyl-1H-imidazol-1-yl)imidazo[1,5-c]pyrimidine-1-carbonitrile::US10676479, Example 6

SMILES Cc1cn(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnc(C#N)c12

InChI Key InChIKey=DGNBZQIVGFSZMN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 450969   

LigandPNGBDBM450969(US10676479, Example 6 | 5-(((5-Fluoro-2,3-dihydrob...)
Affinity DataIC50: 3.10nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450969(US10676479, Example 6 | 5-(((5-Fluoro-2,3-dihydrob...)
Affinity DataIC50: 4.20nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450969(US10676479, Example 6 | 5-(((5-Fluoro-2,3-dihydrob...)
Affinity DataIC50: 12.5nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent