BDBM450980 1-Ethynyl-N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)imidazo[1,5-c]pyrimidin-5-amine::US10676479, Example 12::US10676479, Example 69

SMILES Cc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnc(C#N)c12

InChI Key InChIKey=ORRSIPZEJAGGKP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 450980   

LigandPNGBDBM450980(US10676479, Example 12 | US10676479, Example 69 | ...)
Affinity DataIC50: 5.40nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450980(US10676479, Example 12 | US10676479, Example 69 | ...)
Affinity DataIC50: 6.80nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450980(US10676479, Example 12 | US10676479, Example 69 | ...)
Affinity DataIC50: 9nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450980(US10676479, Example 12 | US10676479, Example 69 | ...)
Affinity DataIC50: 14.1nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450980(US10676479, Example 12 | US10676479, Example 69 | ...)
Affinity DataIC50: 14.7nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450980(US10676479, Example 12 | US10676479, Example 69 | ...)
Affinity DataIC50: 48.9nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent