BDBM451049 5-(((5-fluoro-2,3-dihydrobenzofuran-4-::US10676479, Example 79

SMILES CS(=O)(=O)c1ccc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnc(C#N)c12

InChI Key InChIKey=FZGJUUQXBJOLLZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 451049   

LigandPNGBDBM451049(US10676479, Example 79 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 5.30nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451049(US10676479, Example 79 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 6.60nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451049(US10676479, Example 79 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 16.7nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent