BDBM452671 2-amino-3-((3-((3R,5R)- 5-(4- chlorophenyl)tetrahydro- furan-3-yl)-1,2,4- oxadiazol-5-yl)methyl)- 7- (trifluoromethyl)imidazo [5,1-f][1,2,4]triazin- 4(3H)-one::US10710994, Example 149

SMILES Nc1nn2c(ncc2c(=O)n1Cc1nc(no1)[C@@H]1CO[C@H](C1)c1ccc(Cl)cc1)C(F)(F)F

InChI Key InChIKey=KDXRBPDHOHGHLI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 452671   

LigandPNGBDBM452671(2-amino-3-((3-((3R,5R)- 5-(4- chlorophenyl)tetrahy...)
Affinity DataIC50: 4.48nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
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LigandPNGBDBM452671(2-amino-3-((3-((3R,5R)- 5-(4- chlorophenyl)tetrahy...)
Affinity DataIC50: 2.10nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent