BDBM453226 US10729691, Example 11

SMILES Cn1cnc2c(Nc3ccc(cc3)-c3cn[nH]c3)nc(nc12)-c1cccc(OCC(=O)NC2CCC2)c1

InChI Key InChIKey=BCJYPQKDTINZEK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 453226   

LigandPNGBDBM453226(US10729691, Example 11)
Affinity DataIC50: 375nMAssay Description:HT1080 cells (as well as other cell types) were plated to confluency in 96-well plates. Cells were exposed to the combination of 10 μM Oligomyci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetPutative sugar transporter(malaria parasite P. falciparum)
Kadmon

US Patent
LigandPNGBDBM453226(US10729691, Example 11)
Affinity DataIC50: 175nMAssay Description:Parasite cultures were seeded in 96-well plates (1% hematocrit, 1-2% starting parasitemia, 100 μL total volume) with varying concentrations of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent