BDBM453530 Benzyl (5-((2S,4S)-1-(2-(2-naphthamido)-4-((1S,4R)-bicyclo[2.2.1]heptan-2-yl)butanoyl)-4-(5-(2-hydroxypropan-2-yl)-1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxamido)-7-amino-6,7-dioxoheptyl)carbamate::US10730832, Example 125

SMILES CC(C)(O)c1cnnn1[C@H]1C[C@H](N(C1)C(=O)C(CCC1CC2CCC1C2)NC(=O)c1ccc2ccccc2c1)C(=O)NC(CCCCNC(=O)OCc1ccccc1)C(O)C(N)=O

InChI Key InChIKey=ZYYXTDOBBJUHEZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 453530   

TargetSerine protease HTRA1(Human)
Orion Ophthalmology

US Patent
LigandPNGBDBM453530(Benzyl (5-((2S,4S)-1-(2-(2-naphthamido)-4-((1S,4R)...)
Affinity DataIC50: 14nMAssay Description:Serial dilutions (1/3) from 1000 μM down to 0.051 μM of test compounds were prepared in dimethyl sulfoxide (DMSO). Then 2 μL of soluti...More data for this Ligand-Target Pair
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Date in BDB:
3/21/2021
Entry Details
US Patent