BDBM453991 US10730863, Example 440::US10730863, Example 445::US10730863, Example 449

SMILES CS(=O)(=O)NC(=O)c1cc(cc(c1)C(F)(F)F)-c1noc(n1)C12CCC(CC1)(CC2)\C=C\c1c(onc1-c1c(Cl)cncc1Cl)C1CC1

InChI Key InChIKey=RWTMCHBISHMDBT-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 453991   

TargetBile acid receptor(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM453991(US10730863, Example 440 | US10730863, Example 449 ...)
Affinity DataEC50:  16nMAssay Description:A Gal4-hFXR fusion construct reporter system was used as the primary assay to characterize compound activity. A construct including 5 copies of the G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM453991(US10730863, Example 440 | US10730863, Example 449 ...)
Affinity DataEC50:  220nMAssay Description:A Gal4-hFXR fusion construct reporter system was used as the primary assay to characterize compound activity. A construct including 5 copies of the G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM453991(US10730863, Example 440 | US10730863, Example 449 ...)
Affinity DataEC50:  400nMAssay Description:A Gal4-hFXR fusion construct reporter system was used as the primary assay to characterize compound activity. A construct including 5 copies of the G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent