BDBM458261 (S)-5-((1-(3-fluorobenzyl)pyrrolidin-3-yl)(methyl)amino)-4-methyl-N-(thiazol-4-yl)pyridine-2-sulfonamide::US10752623, Example 5

SMILES CN([C@H]1CCN(Cc2cccc(F)c2)C1)c1cnc(cc1C)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=DJFUXPHZXBXNLT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 458261   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458261((S)-5-((1-(3-fluorobenzyl)pyrrolidin-3-yl)(methyl)...)
Affinity DataIC50: 195nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458261((S)-5-((1-(3-fluorobenzyl)pyrrolidin-3-yl)(methyl)...)
Affinity DataIC50: 2.60E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458261((S)-5-((1-(3-fluorobenzyl)pyrrolidin-3-yl)(methyl)...)
Affinity DataIC50: 3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent