BDBM458292 (R)-N-(6-fluoropyridin-2-yl)-5-methyl-6-(methyl(1-(1-phenylethyl)piperidin-4-yl)amino)pyridine-3-sulfonamide trifluoroacetic acid salt::US10752623, Example 12

SMILES C[C@@H](N1CCC(CC1)N(C)c1ncc(cc1C)S(=O)(=O)Nc1cccc(F)n1)c1ccccc1

InChI Key InChIKey=SZEOVDXXHHINCC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 458292   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458292((R)-N-(6-fluoropyridin-2-yl)-5-methyl-6-(methyl(1-...)
Affinity DataIC50: 90nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458292((R)-N-(6-fluoropyridin-2-yl)-5-methyl-6-(methyl(1-...)
Affinity DataIC50: 3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458292((R)-N-(6-fluoropyridin-2-yl)-5-methyl-6-(methyl(1-...)
Affinity DataIC50: 3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent