BDBM458304 (R)-5-((1-(1-(2-fluorophenyl)ethyl)piperidin-4-yl)(methyl)amino)-N-(6-fluoropyridin-2-yl)-4-methylthiazole-2-sulfonamide triethylammonium salt::US10752623, Example 24

SMILES C[C@@H](N1CCC(CC1)N(C)c1sc(nc1C)S(=O)(=O)Nc1cccc(F)n1)c1ccccc1F

InChI Key InChIKey=XCVXMOSTQLIATQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 458304   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458304((R)-5-((1-(1-(2-fluorophenyl)ethyl)piperidin-4-yl)...)
Affinity DataIC50: 81nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458304((R)-5-((1-(1-(2-fluorophenyl)ethyl)piperidin-4-yl)...)
Affinity DataIC50: 3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458304((R)-5-((1-(1-(2-fluorophenyl)ethyl)piperidin-4-yl)...)
Affinity DataIC50: 3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent