BDBM458305 3-fluoro-5-((1-(2-fluorobenzyl)piperidin-4-yl)(methyl)amino)-N-(6-fluoropyridin-2-yl)-4-methylpyridine-2-sulfonamide trifluoroacetic acid salt::US10752623, Example 25

SMILES CN(C1CCN(Cc2ccccc2F)CC1)c1cnc(c(F)c1C)S(=O)(=O)Nc1cccc(F)n1

InChI Key InChIKey=OVYARDCMVLNIME-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 458305   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458305(3-fluoro-5-((1-(2-fluorobenzyl)piperidin-4-yl)(met...)
Affinity DataIC50: 19nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458305(3-fluoro-5-((1-(2-fluorobenzyl)piperidin-4-yl)(met...)
Affinity DataIC50: 7.08E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458305(3-fluoro-5-((1-(2-fluorobenzyl)piperidin-4-yl)(met...)
Affinity DataIC50: 1.55E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent