BDBM458316 5-((1-benzylpiperidin-4-yl)oxy)-N-(6-fluoropyridin-2-yl)-4-(trifluoromethyl)pyridine-2-sulfonamide::US10752623, Example 36

SMILES Fc1cccc(NS(=O)(=O)c2cc(c(OC3CCN(Cc4ccccc4)CC3)cn2)C(F)(F)F)n1

InChI Key InChIKey=LOEIOUFEFDPFQL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 458316   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458316(5-((1-benzylpiperidin-4-yl)oxy)-N-(6-fluoropyridin...)
Affinity DataIC50: 250nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458316(5-((1-benzylpiperidin-4-yl)oxy)-N-(6-fluoropyridin...)
Affinity DataIC50: 1.74E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458316(5-((1-benzylpiperidin-4-yl)oxy)-N-(6-fluoropyridin...)
Affinity DataIC50: 2.04E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent