BDBM458324 (R)-N-(6-fluoropyridin-2-yl)-4-methyl-5-(methyl(1-(1-phenylethyl)piperidin-4-yl)amino)thiazole-2-sulfonamide formic acid salt::US10752623, Example 44

SMILES C[C@@H](N1CCC(CC1)N(C)c1sc(nc1C)S(=O)(=O)Nc1cccc(F)n1)c1ccccc1

InChI Key InChIKey=LUKROTNEPXUQMR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 458324   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458324((R)-N-(6-fluoropyridin-2-yl)-4-methyl-5-(methyl(1-...)
Affinity DataIC50: 38nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458324((R)-N-(6-fluoropyridin-2-yl)-4-methyl-5-(methyl(1-...)
Affinity DataIC50: 3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458324((R)-N-(6-fluoropyridin-2-yl)-4-methyl-5-(methyl(1-...)
Affinity DataIC50: 3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent