BDBM458334 5-(((1R,5S,8r)-3-benzyl-3-azabicyclo[3.2.1]octan-8-yl)(methyl)amino)-4-methyl-N-(thiazol-4-yl)pyridine-2-sulfonamide trifluoroacetic acid salt::US10752623, Example 54

SMILES CN([C@@H]1[C@H]2CC[C@@H]1CN(Cc1ccccc1)C2)c1cnc(cc1Cl)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=YDQPBEDZXONMIR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 458334   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458334(5-(((1R,5S,8r)-3-benzyl-3-azabicyclo[3.2.1]octan-8...)
Affinity DataIC50: 234nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458334(5-(((1R,5S,8r)-3-benzyl-3-azabicyclo[3.2.1]octan-8...)
Affinity DataIC50: 9.30E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458334(5-(((1R,5S,8r)-3-benzyl-3-azabicyclo[3.2.1]octan-8...)
Affinity DataIC50: 2.71E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent